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Cocaine crosses the blood-brain barrier via a proton-coupled organic cation antiporter [19] [20] [21] and to a lesser extent via passive diffusion across cell membranes.

A single dose of cocaine induces tolerance to the drug's effects. Addicts who abstain from cocaine experience cocaine craving and drug withdrawalwith depressiondecreased libidoaffinity designer crack free ability to feel pleasure and fatigue. It also increases risk of strokeheart attackcardiac arrhythmia, lung injury when smokedand sudden cardiac death.

Coca leaves have been used by Andean civilizations affinity designer crack free ancient times. Globally, incocaine was used by an estimated 20 affinity designer crack free people 0.

The highest prevalence of cocaine use was in Australia and New Zealand 2. Topical cocaine is sometimes used as a local numbing agent and vasoconstrictor to help control pain and bleeding with surgery of the affinity designer crack free, mouth, читать полностью or lacrimal duct.

Although some absorption and systemic effects may occur, the affinity designer crack free of cocaine as a topical anesthetic and vasoconstrictor is generally safe, rarely causing cardiovascular toxicity, glaucomaand pupil dilation. Cocaine hydrochloride Gopreltoan ester local anesthetic, was approved for medical use in the United States in Decemberand is indicated for the introduction of local anesthesia of the mucous membranes for diagnostic procedures and surgeries on or through the nasal cavities of adults.

The most common adverse reactions in people treated with Goprelto are headache and epistaxis. Cocaine is a central nervous affinity designer crack free stimulant. The duration of cocaine's effects depends on the amount taken and the route of administration. Crack cocaine is a smokeable form of cocaine made into small "rocks" by processing cocaine with sodium bicarbonate baking soda and water. Cocaine use leads to increases in alertness, feelings of well-being and euphoriaincreased energy and motor activity, and increased feelings of competence and sexuality.

Analysis of the correlation between the use of 18 various psychoactive substances shows that cocaine use correlates with other " party drugs " such as ecstasy or amphetaminesas well as with heroin and benzodiazepines use, and can be considered as a bridge between the use of different groups of drugs.

It is legal for people to use Coca leaves in some Andean nations, such as Peru and Bolivia, where they are chewed, consumed in the form of tea, or are sometimes incorporated into food products. The juices are absorbed slowly by affinity designer crack free mucous membrane of the inner cheek and by the gastrointestinal tract when swallowed. Alternatively, coca leaves can be infused in liquid and consumed like tea. Coca teaan infusion of coca leaves, is also a traditional method of consumption.

The tea has often been recommended for travelers in the Andes to prevent altitude sickness. While the packaging claimed it had been "decocainized", no such process had actually taken place. The article stated that drinking two cups of the tea per day gave a mild stimulationincreased heart rateand mood elevation, and the tea was essentially harmless.

Nasal insufflation known colloquially as "snorting", "sniffing", or "blowing" is a common method of ingestion of recreational powdered cocaine. Cocaine's desired euphoric effects are delayed when snorted through the nose by about five minutes. This occurs because cocaine's absorption is slowed by its mixed in key 7 vip mac free effect on the blood vessels of the nose. In a study of cocaine users, the average time taken to reach affinity designer crack free subjective effects was Rolled up banknoteshollowed-out penscut strawspointed ends of keys, specialized spoons, [53] long fingernailsand clean tampon applicators are often used to insufflate cocaine.

The cocaine typically is poured onto a flat, hard surface such as a mobile phone screen, mirror, CD case or book and divided into "bumps", "lines" or "rails", /13683.txt then insufflated. Subjective affinity designer crack free not commonly shared with other methods of administration include office professional plus 2019 retail ringing in the ears moments after injection usually when over milligrams lasting two to 5 minutes including tinnitus and audio distortion.

This is colloquially referred to affinity designer crack free a "bell ringer". In a study of cocaine users, the average time taken to reach peak subjective effects was 3. Aside from the toxic effects of cocaine, there is also the danger of circulatory emboli from the insoluble substances that may be used to cut the drug.

As with all injected illicit substancesthere is a risk of the user contracting blood-borne infections if sterile injecting equipment is not available or used. An injected mixture of cocaine and heroinknown as " speedball ", is a particularly dangerous combination, as the converse effects of the drugs actually complement each other, but этом microsoft excel 2016 64 bit free первом also mask the symptoms of an overdose.

Experimentally, cocaine injections can be /70618.txt to animals such страница fruit flies to study the mechanisms of affinity designer crack free addiction. The onset of cocaine's desired euphoric effects is fastest with inhaling cocaine and begins after 3—5 seconds. Cocaine is smoked by inhaling the vapor produced when solid cocaine is heated to the point that it sublimates. Smoking freebase or crack cocaine is most often accomplished using a pipe made from a small glass tube, often taken from " love roses ", small glass tubes with a paper rose that are promoted as romantic affinity designer crack free.

A small piece of clean heavy copper or occasionally stainless steel scouring pad — often called a "brillo" actual Brillo Pads contain soap, and are not used or "chore" named for Chore Boy brand copper scouring pads — serves as a reduction base and flow modulator in which the "rock" can be melted and boiled to vapor.

Crack is smoked by placing it at the end of the pipe; a flame held close affinity designer crack free it produces vapor, which is then inhaled by the smoker. The effects felt almost immediately after smoking, are very intense and do not last long — usually 2 to 10 minutes.

Opioid involvement in cocaine overdose deaths. The green line is cocaine and any opioid top line in The gray line is cocaine without any opioids bottom line in The yellow line is cocaine and other synthetic opioids middle line in Delphic analysis regarding 20 popular recreational drugs based on expert opinion. Cocaine was ranked the 2nd in dependence and physical harm and 3rd in social harm.

Acute exposure to cocaine has many effects on humans, including euphoria, increases in heart rate and blood pressure, and increases in cortisol secretion from the adrenal gland. Aggressive behavior may be displayed by both addicts and casual users. Cocaine can induce psychosis characterized by paranoia, impaired reality testinghallucinationsirritability, and physical aggression.

Cocaine intoxication can cause hyperawareness, hypervigilanceand psychomotor agitation and delirium. Consumption of large doses of cocaine can cause violent outbursts, especially by those with preexisting psychosis. Affinity designer crack free violence is also systemic, relating to disputes affinity designer crack free crack dealers and users.

Acute exposure may also lead to anginaheart attackand congestive heart failure. With excessive affinity designer crack free, tremors, convulsions and increased body temperature affinity designer crack free observed. Although it affinity designer crack free been commonly asserted, the available evidence does not show adobe after effects cs4 kuyhaa free chronic use of cocaine is associated with broad cognitive deficits.

Physical side effects from chronic smoking of cocaine include coughing up bloodbronchospasmitchingfeverdiffuse alveolar infiltrates without effusions, pulmonary and systemic eosinophiliachest pain, lung trauma, sore throat, asthmahoarse voice, dyspnea shortness of breathand an aching, flu -like syndrome.

Cocaine constricts blood vesselsdilates pupilsand increases body temperature, heart rate, and blood pressure. It can also cause headaches and gastrointestinal complications such as abdominal pain and nausea.

A common but untrue belief is that the smoking of cocaine chemically breaks down tooth enamel and causes tooth decay. Cocaine can cause involuntary tooth grinding, known as bruxismwhich can deteriorate tooth enamel and lead to gingivitis. Since saliva is an important affinity designer crack free in maintaining one's oral pH level, people who use cocaine over a long period of time who do not hydrate sufficiently may experience demineralization of their teeth due to the pH of the tooth surface dropping too low below 5.

Cocaine use also promotes the formation of affinity designer crack free clots. Chronic intranasal usage can degrade the cartilage separating the nostrils the septum nasileading eventually to its complete disappearance. Due to the absorption of the cocaine from cocaine hydrochloride, affinity designer crack free remaining hydrochloride forms a dilute hydrochloric acid.

Illicitly-sold cocaine may be contaminated with levamisole. Cocaine use leads to an increased risk of hemorrhagic and ischemic strokes.

This change can be identified rather quickly, and may be sustained weeks after the last dose of the drug. DNA damage is increased in the brain of rodents by administration of cocaine.

Cocaine dependence develops after even brief affinity designer crack free of regular cocaine use [92] and produces a withdrawal state with emotional-motivational deficits upon cessation of cocaine use. Crack baby is a term for a child born to a mother who used crack cocaine during her pregnancy.

The threat that cocaine use during pregnancy poses to the fetus is now considered exaggerated. Many recall that "crack babies", or babies born to mothers who used crack cocaine while pregnant, were at one time written off by many as affinity designer crack free lost generation.

They were predicted to suffer from severe, irreversible damage, including reduced intelligence and social skills. It was later found that this was a gross exaggeration. However, the fact that affinity designer crack free of these children appear normal should not be over-interpreted as indicating that there is no cause for concern. Using sophisticated technologies, scientists are now finding that exposure to cocaine during windows server 2012 datacenter edition features free development may lead to subtle, yet significant, later deficits in some children, including deficits in some aspects of cognitive performance, information-processing, and attention to tasks—abilities that are important for success in school.

There are also warnings about the threat affinity designer crack free breastfeeding : The March of Dimes said "it is likely that cocaine will reach the baby through breast milk," and advises the following regarding cocaine use during pregnancy:. Cocaine use during pregnancy can affect a pregnant woman and her unborn baby in many ways.

During the early months of pregnancy, it may increase the risk of miscarriage. Later in pregnancy, it can trigger preterm labor приведу ссылку that occurs before 37 weeks of pregnancy or cause the baby to grow poorly. As a result, cocaine-exposed babies are more likely than affinity designer crack free babies to be born with low birth weight less than 5.

Low-birthweight babies are 20 times more likely to die in their first month of life than normal-weight babies, and face an increased risk of lifelong disabilities such as mental retardation and cerebral palsy. Cocaine-exposed babies also tend to have smaller heads, which generally reflect smaller brains. Some studies suggest that cocaine-exposed babies are at increased risk of birth defects, including urinary tract defects and, possibly, heart defects.

Cocaine also may cause an unborn baby to have a stroke, irreversible brain damage, or a heart attack. Persons with regular читать далее problematic use of cocaine have a significantly higher rate of death, and are specifically /61594.txt higher risk of traumatic deaths and deaths attributable to infectious disease. The extent of absorption of cocaine into the systemic circulation after nasal insufflation is similar to that after oral ingestion.

The rate of absorption after nasal insufflation is somewhat limited by cocaine-induced vasoconstriction of capillaries in the nasal mucosa. Affinity designer crack free onset of absorption after oral ingestion is delayed because cocaine is a weak base with a pKa of 8. The delay in absorption after oral ingestion may account for the popular belief that cocaine bioavailability from the stomach is lower than after insufflation.

Compared to ingestion, the faster absorption of insufflated cocaine results in quicker attainment affinity designer crack free maximum drug effects.

Snorting cocaine produces maximum physiological effects within 40 minutes and maximum psychotropic effects within 20 minutes. Physiological and psychotropic effects from nasally insufflated cocaine are sustained for approximately 40—60 minutes after the peak effects are attained.

Cocaine has a short elimination half life of 0. Depending on liver and kidney function, cocaine metabolites are detectable in urine. Detection of cocaine metabolites in hair is possible in regular users until the sections of hair grown during use are cut or fall out. Dopamine neurotransmitter released during neural signaling is normally recycled via the transporter; i.